RepurposingRiluzoleAugmentBrainDerivedNeuropathFactorLevel&CogFunc BreastCaPa ExpCa-Related CogImpai

UCI Specialty Area: Cancer

Principal Investigator: Alexandre Chan

Official Title: Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Breast Cancer Patients Experiencing Cancer-Related Cognitive Impairment: An Interventional Pilot Clinical Trial

A Study On:

Breast

Study Description

This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels of breast cancer survivors with cancer related cognitive impairment.

Eligibility

• Diagnosed with breast cancer

• Past exposure to chemotherapy, radiotherapy, surgery, and/or other breast cancer interventions

• ≥18 years of age

• Perceived that cognitive function has worsened since cancer diagnosis and/or beginning of cancer treatment

• Able to provide informed consent

• Must agree to complete and able to complete the questionnaires and computerized assessments

• Presence of metastases

• Unwilling to undergo neuropsychological assessments necessary for the study

• Breastfeeding, pregnant or are planning get pregnant during the study period

• History of or suspected hypersensitivity to riluzole or to any of its inactive ingredients

• Patients taking or planning to take medications/substances with potential drug-drug interactions

• Hepatic impairment: Patients with measured serum transaminases 3 times greater than upper limit of normal

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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