Descartes-15 for Pts w/Relap/Refr MultipleMyeloma

UCI Specialty Area: Cancer

Principal Investigator: Stefan Octavian Ciurea

Official Title: Descartes-15 for Patients with Relapsed/Refractory Multiple Myeloma

A Study On:

Multiple Myeloma

Study Description

This is a Phase I dose-escalation study to evaluate the safety, tolerability and preliminary efficacy of an autologous BCMA-targeting RNA-engineered CAR T-cell therapy in patients with Relapsed/Refractory Multiple Myeloma. The cell product is referred to as Descartes-15

Eligibility

-Patients must be diagnosed with active and measurable relapsed/refractory multiple myeloma.

-Patients must have failed at least 3 prior lines of therapy which must have included an immunomodulatory drug, a proteasome inhibitor, and an anti-CD38 drug or biologic.

-Patients must have clinical performance status of ECOG 0-2.

-Patients must have adequate vital organ function as defined by:

-Patient must have labs drawn

-Normal cardiac and pulmonary function

-No thromboembolic events in the past 3 months

-No heparin allergy or active infection

-Patients who have any active and uncontrolled infection.

-Ongoing treatment with chronic immunosuppressants (e.g., cyclosporine or systemic steroids above 40 mg/day prednisone equivalent).

-Patients who have active central nervous system disease.

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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Please read the information below and ask questions about anything that you do not understand. A
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immediately.

You are eligible to participate in this study if you may be interested in participating in a research trial at UCI Health

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Future Research Use
Researchers will use your information to conduct this study. Once the study is done using your information, we may share them with other researchers so they can use them for other studies in the future. We will not share your name or any other private identifiable information that would let the researchers know who you are. We will not ask you for additional permission to share this de-identified information

Data Retention - In accordance with UC Office of the President policy, information will be retained for 10 years after the end of the calendar year in which the research is completed.

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