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PhII EvalSafTolerabEfficPK&Immu AZD0901 Monothe&Combw/AntiCa Agen Partic w/AdvSolTuExpresClaudin18.2

UCI Specialty Area: Cancer
Principal Investigator: Farshid Dayyani
Official Title: A Phase II, Open-Label, Multi-Centre Study to Evaluate Safety, Tolerability, Efficacy, PK, and Immunogenicity of AZD0901 as Monotherapy and in Combination with Anti-Cancer Agents in Participants with Advanced Solid Tumours Expressing Claudin 18.2.
A Study On:
Esophagus
Pancreas
Stomach

Study Description

The purpose of this study is to assess the safety, tolerability, efficacy, pharmacokinetics (PK), and immunogenicity of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced unresectable or metastatic solid tumours expressing CLDN18.2.

Eligibility

-Participant must be at least 18 years of age at the time of signing the informed consent form (ICF)

  • Body weight greater than 35 kg

-Participants who are CLDN18.2 positive

  • uncontrolled diabetes or diabetic neuropathy within 3 months prior to the first dose of study intervention

-Any concurrent anti-cancer treatment

  • Current pregnant or breastfeeding or planning to become pregnant
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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

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