Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hep & Pancreatic Ca

UCI Specialty Area: Cancer

Principal Investigator: Nadine Abi-Jaoudeh

Official Title: Pilot Trial Comparing Circulating Tumor DNA (ctDNA) From Immediate Draining Vein vs. Standard Peripheral Vein Sample in Patients Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

A Study On:

Liver

Other Digestive Organ

Pancreas

Study Description

This is a, prospective single center pilot study to investigate whether ctDNA detection can be improved by sampling the cancer draining vein vs. a peripheral vein (current practice). As a secondary endpoint, both ctDNA results will be compared with percutaneous biopsy (standard of care).

Eligibility

You can participate in this study if you

Are 18 years of age or older
Have or are undergoing work-up for hepatobiliary and/or pancreatic cancer
Are scheduled for an image-guided percutaneous or trans-jugular biopsy of a lesion

You cannot participate in this study if you

Have a gross body weight over 375 pounds
Have moderate to severe ascites (abdominal swelling caused by accumulation of fluid)

and unable to undergo trans-jugular biopsy or sufficient drainage

Cannot have a peripheral blood draw for ctDNA

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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