PhIIIMirvetuximabSoravtansineCombW/BevacizumabVSBevacizumab PaW/FrA+After2ndLine PlatinumChemo +Bev

UCI Specialty Area: Cancer

Principal Investigator: Krishnansu Tewari

Official Title: Randomized, Multicenter, Open-label, Phase III Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FrA-positive Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab

A Study On:

Cervix

Corpus Uteri

Other Female Genital

Ovary

Study Description

Randomized, multicenter, open-label, Phase 3 study of mirvetuximab

soravtansine in combination with bevacizumab versus bevacizumab

alone as maintenance therapy for patients with FRα-high recurrent

platinum-sensitive epithelial ovarian, fallopian tube, or primary

peritoneal cancers who have not progressed after second-line platinumbased

chemotherapy plus bevacizumab (GLORIOSA)

Eligibility

Patients must be <18 years of age.
Patients must have an Eastern Cooperative Oncology Group performance status of 0 or 1.
Patients must have a confirmed diagnosis of high-grade serous epithelial ovarian, primary

peritoneal, or fallopian tube cancer

Patients with PD while on or following platinum-based triplet therapy
Patients with prior wide-field radiotherapy affecting at least 20% of the bone marrow
Patients with > Grade 1 peripheral neuropathy per Common Terminology Criteria for

Adverse Events (CTCAE)

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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