Ph II Trial of SMO/AKT/NF2 Inhibitors in Progressive Meningiomas w/ SMO/ AKT/ NF2 Mutations

UCI Specialty Area: Cancer

Principal Investigator: Daniela Bota

Official Title: Phase II Trial of SMO/AKT/NF2/CDK Inhibitors in Progressive Meningiomas with SMO/ AKT/ NF2 /CDK Pathway Mutations

A Study On:

Brain and Nervous System

Study Description

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Eligibility

Histologically proven intracranial meningioma as documented by

central pathology review

Presence of SMO, PTCH1, NF2, CDKN2A, AKT1, PIK3CA, PTEN

mutations, CDKN2A copy number loss, CDK4, CDK6, CCND1, CCND2, CCND3, or CCNE1

copy number gain in tumor sample as documented specifically by the central laboratory

Male or female who are not pregnant and not nursing

Patients who have active bacterial infection
Patients who have history of heart diseases as described by the study protocol
Patients who have uncontrolled hypertension

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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