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PhII/III NABPLAGEMvsNabPaclitaxel/Gemcitabine BRCA1/2PALB2MutantMetaPancreaticDuctalAdenoCa

UCI Specialty Area: Cancer
Principal Investigator: Jennifer Brooke Valerin
Official Title: Phase II/III Second-Line NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Mutant Metastatic Pancreatic Ductal Adenocarcinoma (PLATINUM)
A Study On:
Pancreas

Study Description

This phase II/III trial compares the effect of the 3-drug chemotherapy combination of nab-paclitaxel, gemcitabine, plus cisplatin versus the 2-drug chemotherapy combination of nab-paclitaxel plus gemcitabine for the treatment of patients with pancreatic cancer that has spread to other places in the body (metastatic) and a known genetic mutation in the BRCA1, BRCA2, or PALB2 gene.

Eligibility

  • Documentation of disease (metastatic pancreatic adenocarcinoma. Adenosquamous carcinoma, squamous carcinoma, acinar cell carcinoma, and carcinoma not otherwise specified are also acceptable)
  • Patients must be at least 18 years of age or older

-Patients must not be pregnant or nursing

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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