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PhIB/IIA CTO1681 Prev&Tx of Cytokine RelSyndrome DiffLargeBCellLymphReceivCAR TCell

UCI Specialty Area: Cancer
Principal Investigator: Stefan Octavian Ciurea
Official Title: Phase IB/IIA Study of CTO1681 for the Prevention and Treatment of Cytokine Release Syndrome in Patients With Diffuse Large B-Cell Lymphoma Receiving Chimeric Antigen Receptor T-Cell Therapy
A Study On:
Non-Hodgkin's Lymphoma

Study Description

This is an interventional study to evaluate the use of CTO1681 in preventing or reducing CAR T-cell-induced toxicities like cytokine release syndrome (CRS). This study will enroll adult patients with DLBCL who are scheduled to receive CD19-directed CAR T-cell therapy.

The first phase of the study will be open label with dose escalation. Participants will start taking CTO1681 just prior to receiving their CAR T-cell therapy and continue to take the study drug three times daily for a total of 15 days.

Eligibility

If you have Previously Untreated Follicular Lymphoma

If you are at least 18 years old.

You cannot participate in this study if you are female who is pregnant or breastfeeding or planning to become pregnant.

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Interested in Participating in this Trial?

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Privacy Policy

University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

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