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Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas

UCI Specialty Area: Cancer
Principal Investigator: Farshid Dayyani
Official Title: Proof of Concept Study of ctDNA Guided Change in Treatment for Refractory Minimal Residual Disease in Colon Adenocarcinomas
A Study On:
Colon
Rectum

Study Description

This is a phase 1b, prospective, single arm, non-randomized, open-label clinical trial determining the efficacy of adjuvant trifluridine and tipiracil (TAS-102) in combination with irinotecan in patients with ctDNA positive colon adenocarcinoma.

Eligibility

Subjects can participate in this study if they satisfy the following criteria:

  • At least 18 years of age
  • Confirmed diagnosis of adenocarcinoma (cancer) of the colon
  • Positive ctDNA assay (test)

Subjects cannot participate in this study if they have any of the following criteria:

  • Previous treatment with either irinotecan or TAS-102
  • Any active infection or other cancers
  • Pregnant or nursing
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Privacy Policy

University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

  • Please read the information below and ask questions about anything that you do not understand. A
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  • Future Research Use
    Researchers will use your information to conduct this study. Once the study is done using your information, we may share them with other researchers so they can use them for other studies in the future. We will not share your name or any other private identifiable information that would let the researchers know who you are. We will not ask you for additional permission to share this de-identified information
  • Data Retention - In accordance with UC Office of the President policy, information will be retained for 10 years after the end of the calendar year in which the research is completed.
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