Ph II of Cabo. w/ Ipi./Nivo. and TACE in Pts w/ HCC (not candidates for Curative Tx)

UCI Specialty Area: Cancer

Principal Investigator: Farshid Dayyani

Official Title: Phase II Study of Cabozantinib Combined with Ipilimumab/Nivolumab and Transarterial Chemoembolization (TACE) in Patients with Hepatocellular Carcinoma (HCC) Who are not Candidates for Curative Intent Treatment

A Study On:

Liver

Study Description

This is a phase 2 single-arm, open-label clinical trial determining efficacy of cabozantinib in combination with ipilimumab/nivolumab and transarterial chemoembolization (TACE) in subjects with hepatocellular carcinoma (HCC). These are subjects who are not candidates for curative intent treatment.

Eligibility

You can participate in this study if you satisfy following criteria:

At least 18 years of age
Biopsy proven or imaging based diagnosis of hepatocellular carcinoma ("primary liver cancer")
Not a candidate for surgery or curative treatment based on your doctor's assessment

You cannot participate in this study if you have any of the following criteria:

Previous treatment with cabozantinib or immunotherapy
Any active infection (except for controlled Hepatitis B or C) or other cancers
Pregnant or nursing

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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Future Research Use
Researchers will use your information to conduct this study. Once the study is done using your information, we may share them with other researchers so they can use them for other studies in the future. We will not share your name or any other private identifiable information that would let the researchers know who you are. We will not ask you for additional permission to share this de-identified information

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