Ph I/II Study of MRTX849 in Pts w/ Adv Solid Tumors w/ KRAS G12C Mutation

UCI Specialty Area: Cancer

Principal Investigator: Sai-Hong Ou

Official Title: A Phase I/II Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation

A Study On:

Anus

Breast

Colon

Hodgkin's Lymphoma

Kaposis sarcoma

Leukemia other

Lung

Lymphoid Leukemia

Melanoma skin

Myeloid and Monocytic Leukemia

Non-Hodgkin's Lymphoma

Other Digestive Organ

Other Endocrine System

Pancreas

Rectum

Small Intestine

Stomach

Study Description

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation

Eligibility

Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation

Unresectable or metastatic disease

Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts

Adequate organ function

History of intestinal disease or major gastric surgery or inability to swallow oral medications

Other active cancer

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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Please read the information below and ask questions about anything that you do not understand. A
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You are eligible to participate in this study if you may be interested in participating in a research trial at UCI Health

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Future Research Use
Researchers will use your information to conduct this study. Once the study is done using your information, we may share them with other researchers so they can use them for other studies in the future. We will not share your name or any other private identifiable information that would let the researchers know who you are. We will not ask you for additional permission to share this de-identified information

Data Retention - In accordance with UC Office of the President policy, information will be retained for 10 years after the end of the calendar year in which the research is completed.

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