Ph Ib/II ACR-368 as Monother& Comb w/Gemcitabine in Plat-Res Ovarian Ca Endometrial Adenoca &Urothel

UCI Specialty Area: Cancer

Principal Investigator: Nataliya Mar

Official Title: A Phase Ib/II Basket Study of ACR-368 as Monotherapy and in Combination with Gemcitabine in Adult Subjects with Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon OncoSignature® Status

A Study On:

Corpus Uteri

Kidney

Other Urinary

Ovary

Urinary Bladder

Study Description

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status.

Eligibility

Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen.
Participant must be willing to provide tissue from a newly obtained tumor biopsy from an accessible tumor lesion not previously irradiated after signed informed consent.
Participant must have an estimated life expectancy of longer than 3 months.

Participant with known symptomatic brain metastases requiring > 10 mg/day of prednisolone (or its equivalent).
Participants has known human immunodeficiency virus, hepatitis B, or hepatitis C infection that is considered uncontrolled

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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