PhII M1774 in Refr SPOP-mutant Prostate Ca

UCI Specialty Area: Cancer

Principal Investigator: Arash Rezazadeh Kalebasty

Official Title: A Phase II Study of M1774 in Refractory SPOP-mutant Prostate Cancer

A Study On:

Prostate

Study Description

This phase II trial tests how well M1774 works in treating patients with prostate cancer that does not respond to treatment (refractory) and that has a mutation in the gene responsible for making the speckle type BTB/POZ protein (SPOP). M1774 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving M1774 may be able to shrink or stabilize refractory SPOP-mutant prostate cancer.

Eligibility

Presence of SPOP mutations in prostate cancer cells, as indicated by Next Generation Sequencing (NGS)
Castrate-range testosterone (< 50 ng/dL) after androgen deprivation therapy (ADT) or orchiectomy
Prior treatment with second generation anti-androgen (2GAA) and taxane- or lutetium-based therapy

Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > grade 1) with the exception of alopecia
Patients who are receiving any other investigational agents
Patients with uncontrolled intercurrent illness

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

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