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Effect of Ultra-Low Dose Naloxone on Remifentanil-Induced Hyperalgesia

UCI Specialty Area: Trauma & Critical Care
Principal Investigator: Ariana Nelson
Official Title: Effect of Ultra-Low Dose Naloxone on Remifentanil-Induced Hyperalgesia
A Study On:
Anesthesia
Hyperalgesia

Study Description

The purpose of this study is to evaluate whether using ultra-low dose naloxone, an opioid antagonist, has the potential to block remifentanil-induced hyperalgesia and tolerance following surgery.

The hypothesis of the study is that occurrence of remifentanil-induced HI group.

Eligibility

  1. Subjects who provide written informed consent.
  2. Age 18 years old or older (no upper age limit for inclusion)
  3. Gender: male or female.
  4. Surgery: Posterior spinal fusions
  1. Allergy to opiates
  2. Chronic pain other than the primary indication for surgery
  3. Psychiatric illness
  4. History of substance abuse problem including alcohol &/or cannabis
  5. BMI > 35
  6. Subjects under 18 years of age.
  7. Subject without the capacity to give written informed consent. 8. Female subjects who are pregnant
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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

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