Effect of Ultra-Low Dose Naloxone on Remifentanil-Induced Hyperalgesia

Trauma & Critical Care
Ariana Nelson
Effect of Ultra-Low Dose Naloxone on Remifentanil-Induced Hyperalgesia
Anesthesia
Hyperalgesia

Study Description

The purpose of this study is to evaluate whether using ultra-low dose naloxone, an opioid antagonist, has the potential to block remifentanil-induced hyperalgesia and tolerance following surgery.

The hypothesis of the study is that occurrence of remifentanil-induced HI group.

Eligibility

  1. Subjects who provide written informed consent.
  2. Age 18 years old or older (no upper age limit for inclusion)
  3. Gender: male or female.
  4. Surgery: Posterior spinal fusions
  1. Allergy to opiates
  2. Chronic pain other than the primary indication for surgery
  3. Psychiatric illness
  4. History of substance abuse problem including alcohol &/or cannabis
  5. BMI > 35
  6. Subjects under 18 years of age.
  7. Subject without the capacity to give written informed consent. 8. Female subjects who are pregnant
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